LONDON - Doctors said on Monday they had transplanted human
ovarian tissue into the muscles
of mice to grow human eggs in a technique that could one day
be used to retain the fertility
of cancer patients.
Scientists from the Samuel Luenfield Research Institute at
Mount Sinai Hospital in Toronto told the European Society
of Human Reproduction and Embryology (ESHRE) conference in
Bologna, Italy that it was the first time tissue from the
human ovarian cortex has been
grafted and yielded eggs. The
ovarian cortex is the surface of the ovary which contains
the follicles that produce the
eggs.
"The possibility of preserving the ovarian cortex prior
to surgery, drug or radiotherapy
treatment offers new hope for young cancer patients,"
Dr Ariel Revel said in a statement released in London.
Revel and his colleague Dr Hila Raanani have used fresh and
frozen ovarian tissue to successfully grow human eggs in mice.
They now plan to see if the eggs retrieved
from the mice muscle mature in the laboratory and if they
are normal.
"If all goes well we could be ready to begin IVF (in
vitro fertilisation) in the first patients in a year or so,"
said Revel.
Fertility centers are already freezing ovarian tissue and
human eggs of women undergoing cancer treatment or other medical
procedures which could damage their fertility. But freezing
can damage the eggs, which are very fragile.
Transplanting the tissue back
into the patients is also difficult. For cancer patients there
is also the danger that the tissue may contain cancerous
cells.
难点词汇:
ovarian 卵巢的 fertility 生殖能力 cortex 皮层,皮质
yield 生长 follicle 小囊,
滤泡 radiotherapy 电气透热疗法
retrieve 重新得到
fragile 脆弱的,易碎的 transplant 移植
cancerous 癌的
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